施一公到底发了多少篇Nature、Science和Cell？

2015年09月，清华大学教授施一公在Science同期发表2篇研究长文，被业界盛赞为“诺贝尔级成果”。同月出任清华大学副校长。

施一公，结构生物学家，中科院院士，美国两院院士。1967年5月5日出生于河南省郑州，1989年毕业于清华大学，1995年在美国约翰霍普金斯大学获博士学位。主要从事细胞凋亡及膜蛋白两个领域的研究。在Smad对TGF-的调控机理、磷酸酶PP2A的结构生物学方面做出过有国际影响的工作。曾获国际赛克勒生物物理学奖、香港求是科技基金会杰出科学家奖、谈家桢生命科学终身成就奖、瑞典皇家科学院颁发的2014年度爱明诺夫奖等奖项。美国艺术与科学院院士、美国国家科学院外籍院士、欧洲分子生物学组织外籍成员。

 

除去不可计数的子刊，施一公在Nature、Science和Cell共发表54篇文章（截止时间2015.09.18，由于文章够多，统计可能略有出入）。对此，小编我只能表示：啧啧啧……

 

Cell正刊（21篇）

1.    Structural Basis of RIP1 Inhibition by Necrostatins

2.    Structural Insights into RIP3-Mediated Necroptotic Signaling

3.    TIPE3 Is the Transfer Protein of Lipid Second Messengers that Promote Cancer

4.    Structure and Mechanism of a Nitrate Transporter

5.    A Glimpse of Structural Biology through X-Ray Crystallography

6.    Crystal structure of the caenorhabditis elegans apoptosome reveals an octameric assembly of CED-4

7.    Serine/Threonine Phosphatases: Mechanism through Structure

8.    Structural Mechanism of Demethylation and Inactivation of Protein Phosphatase 2A

9.    Allosteric Activation of a Bacterial Stress Sensor

10. Structure of the Protein Phosphatase 2A Holoenzyme

11. Structure of Protein Phosphatase 2A Core Enzyme Bound to Tumor-Inducing Toxins

12. PPM1A Functions as a Smad Phosphatase to Terminate TGFβ Signaling

13. Molecular mechanism of AHSP-mediated stabilization of α-hemoglobin

14. Caspase activation: Revisiting the induced proximity model

15. Mechanisms of TGF-β signaling from cell membrane to the nucleus

16. Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde

17. Structural mechanism of Smad4 recognition by the nuclear oncoprotein Ski: Insights on Ski-mediated repression of TGF-β signaling

18. Crystal structure of a procaspase-7 zymogen: Mechanisms of activation and substrate binding

19. Structural basis of caspase-7 inhibition by XIAP

20. Crystal structure of the PTEN tumor suppressor: Implications for its phosphoinositide phosphatase activity and membrane association

21. Crystal structure of a Smad MH1 domain bound to DNA: Insights on DNA binding in TGF-β signaling

 

Nature正刊(23篇)

22. An atomic structure of human γ-secretase

23. Crystal structures of the Lsm complex bound to the 3′ end sequence of U6 small nuclear RNA

24. Structure of a bacterial energy-coupling factor transporter

25. Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolution

26. Three-dimensional structure of human γ-secretase

27. Structural basis for the modular recognition of single-stranded RNA by PPR proteins

28. Structure of a presenilin family intramembrane aspartate protease

29. Structural basis of ultraviolet-B perception by UVR8

30. Structure and mechanism of a glutamate-GABA antiporter

31. Structure and mechanism of the hexameric MecA-ClpC molecular machine

32. Structure and mechanism of the S component of a bacterial ECF transporter

33. Mechanism of substrate recognition and transport by an amino acid antiporter

34. Structure of the formate transporter FocA reveals a pentameric aquaporin-like channel

35. Chaperone-mediated pathway of proteasome regulatory particle assembly

36. Structure and metal exchange in the cadmium carbonic anhydrase of marine diatoms

37. Structure of the CED-4-CED-9 complex provides insights into programmed cell death in Caenorhabditis elegans

38. Structure of oxidized α-haemoglobin bound to AHSP reveals a protective mechanism for haem

39. Structure of the apoptotic protease-activating factor 1 bound to ADP

40. A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis

41. Structural basis of IAP recognition by Smac/DIABLO

42. Structural and biochemical basis of apoptotic activation by Smac/DIABLO

43. Structural basis of procaspase-9 recruitment by the apoptotic protease- activating factor 1

44. A structural basis for mutational inactivation of the tumour suppressor Smad4

 

Science(10篇)

45. Structure of a yeast spliceosome at 3.6-angstrom resolution

46. Structural basis of pre-mRNA splicing

47. Structural basis for sequence-specific recognition of DNA by TAL effectors

48. China's research culture

49. Structure and mechanism of an amino acid antiporter

50. Structure of a site-2 protease family intramembrane metalloprotease

51. Mechanisms of AIF-mediated apoptotic DNA degradation in Caenorhabditis elegans

52. Structural basis of Smad2 recognition by the smad anchor for receptor activation

53. The galvanization of biology: A growing appreciation for the roles of zinc

54. Specific DNA-RNA hybrid binding by zinc finger proteins

 

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